韩俊伟，教授，博士研究生。
办公电话：045186669617，办公地址：分子生物学馆219。
E-mail：hanjunwei@ems.hrbmu.edu.cn，
主要研究方向
生物信息学，人工智能和机器学习
个人简介
韩俊伟，教授，博士生导师，黑龙江省高层次人才入选者，星联青年学者，哈尔滨市科技创新人才，独立PI。担任国家自然科学基金通讯评审专家。研究方向：生物学功能注释及肿瘤标志物相关研究。以负责人承担国家自然科学基金（面上2、青年1）、中国博士后基金、黑龙江省自然科学基金及哈尔滨科技创新人才项目等各类课题。研究成果发表在《Molecular Oncology》、《Briefings in Bioinformatics》、《Bioinformatics》等杂志上，以第一和通讯作者发表SCI文章40余篇。开发生物学应用软件20余个。获黑龙江省科学技术奖二等奖1项。现任中国计算机学会生物信息学专业委员会执行委员、中国自动化学会智能健康与生物信息专业委员会委员、中国人工智能学会生物信息学与人工生命专业委员会委员、中国抗癌协会肿瘤标志专业委员会肿瘤测序及大数据分析专业委员会委员。
学术兼职
1、中国计算机学会生物信息学专业委员会执行委员
2、中国自动化学会智能健康与生物信息专业委员会委员
3、中国人工智能学会生物信息学与人工生命专业委员会委员
4、中国抗癌协会肿瘤标志青委会委员
5、中国生物信息学会（筹）表观遗传信息学专业委员会委员
6、中国生物信息学会（筹）多组学与整合生物学业委员会委员
7、中国抗癌协会肿瘤标志专业委员会肿瘤测序及大数据分析专业委员会委员
主持科研项目
(1)国家自然科学基金委员会,面上项目,62372143,癌症个体化通路网络特征模型的构建与分析方法研究,2024-01-01至2027-12-31,在研,主持
(2)国家自然科学基金委员会,面上项目,62072145,基于生物学通路网络的癌症标志物识别方法研究,2021-01-01至2024-12-31,在研,主持
(3)国家自然科学基金委员会,青年项目,31401127,基于通路内部结构与通路间crosstalk识别复杂疾病风险通路的研究, 2015-01-01至2018-12-31,结题,主持
(4)黑龙省自然科学基金,联合引导项目,LH2019C042,基于癌症基因转录组大数据识别癌症风险子通路和生物标志物的研究,2019-07至2022-07,在研,主持
(5)黑龙江省博士后基金,启动金,LBH-Q18077,基于通路拓扑结构识别癌症风险通路区域和生物标志物的系统生物学研究,2018-12至2021-12,结题,主持
(6)哈尔滨市科技局,科技创新人才,2017RAQXJ195,基于网络扩散算法识别癌症风险通路的研究,2017-09至2019-12,结题,主持
(7)中国博士后科学基金,面上,2016M601443,基于网络扩散算法识别癌症风险通路的研究,2016-11至2018-05,结题,主持
(8)黑龙江省博士后基金,面上,LBH-Z16130,基于通路拓扑结构识别癌症风险通路区域和生物标志物的系统,2016-03至2018-03,结题,主持
主持及参与教学项目
1、黑龙江省高等公司产品改革项目（重点项目），《生物信息学》课程科研教学一体化模式的研究与实践，2014年07月-2016年09月，主持人。
科研成果奖励
(1)基于多关联数据融合的疾病相似度算法研究,黑龙江省科学技术奖二等奖,韩俊伟(2/3);2020。
教学成果奖励
（1）黑龙江省高等教育学会优秀高等教育研究成果二等奖，主持，2017
（2）英国beat365官方网站入口教学成果奖，主持，2019
指导学生获奖
（1）全国大学生数学建模竞赛一等奖，江泽东，邢杰，唐康，2017。指导教师：韩俊伟
（2）全国大学生数学建模竞赛黑龙江省一等奖，杨景，岁月，李国齐，2017。指导教师：韩俊伟
（3）全国大学生数学建模竞赛黑龙江省一等奖，李香妹，陶俊贤，邹敏，2018。指导教师：韩俊伟
（4）全国大学生数学建模竞赛黑龙江省一等奖，陈淑华，金璐，刘文清，2018。指导教师：韩俊伟
（5）多次指导学生获东北三省数学建模竞赛一等奖
（6）多次指导学生获美国数学建模竞赛S奖
指导大学生创新项目
利用基因表达值秩次关系构建胃癌组织与非癌组织（正常、炎症）的鉴别标志（No.201810226010）,大学生创新创业项目（国家级）,指导教师：韩俊伟
发表SCI论文
近3年，第一通讯与第一作者论文
(1)Yuqi Sheng,Jiashuo Wu,Xiangmei Li,Jiayue Qiu,Ji Li,Qinyu Ge,Liang Cheng,Junwei Han;iATMEcell: identification of abnormal tumor microenvironment cells to predict the clinical outcomes in cancer based on cell–cell crosstalk network,Briefings in Bioinformatics,2023 Mar 19;24(2):bbad074
(2)Qian Wang, Xiangmei Li, Jiayue Qiu, Yalan He, Jiashuo Wu, Ji Li, Wei Liu,Junwei Han;A pathway-based mutation signature to predict the clinical outcomes and response to CTLA-4 inhibitors in melanoma,Computational and Structural Biotechnology Journal,2023, 21: 365-377.
(3)YinchunSu, Jiashuo Wu, Xiangmei Li, Ji Li, Xilong Zhao, Bingyue Pan, Junling Huang, Qingfei Kong ,Junwei Han; DTSEA: A network-based drug target set enrichment analysis method for drug repurposing against COVID-19,Computers in Biologyand Medicine,2023, 159, 106969.
(4)Xiangmei Li, Yalan He, Ying Jiang, Bingyue Pan, Jiashuo Wu, Xilong Zhao, Junling Huang, Qian Wang, Liang Cheng,Junwei Han;PathwayTMB: A pathway-based tumor mutational burden analysis method for predicting the clinical outcome of cancer immunotherapy,Molecular Therapy - Nucleic Acids,2023, 09.003.
(5)Wu,Jiashuo; Li,Xiangmei;Wang.Qian;Han,Junwei;DRviaSPCN: a software package for drug repurposing in cancer via a subpathway crosstalk network,Bioinformatics, 2022, 8(21):4975-4977
(6)Li,Xiangmei;He,Yalan; Wu.Jiashuo; Qiu,Jiayue;Ji Li; Wang,Qian;Jiang,Ying;Junwei Han; Anovel pathway mutation perturbation score predicts the clinical outcomes of immunotherapy,Briefings in Bioinformatics,2022,23(5):bbac360
(7)Qiu, Jiayue; Li, Xiangmei; He, Yalan; Wang, Qian; Li, Ji; Wu, Jiashuo; Jiang, Ying;Han, Junwei；Identification of comutation in signaling pathways to predict the clinical outcomes of immunotherapy,Journal of Translational Medicine, 2022, 20(1): 613.
(8)Han,Junwei;Yang, Yang; Li, Xiangmei; Wu, Jiashuo; Sheng, Yuqi; Qiu, Jiayue; Wang, Qian;Li, Ji; He, Yalan; Cheng, Liang; Zhang, Yan;Pan-cancer analysis reveals sex-specific signatures in the tumor microenvironment.,Molecular Oncology, 2022, 16(11):2153-2173.
(9)Wang, Wei; Yuan, Haiyan;Han, Junwei;Liu, Wei,PCLassoLog: A protein complex-based, group Lasso-logistic model for cancer classification and risk protein complex discovery,Computational and Structural Biotechnology Journal,2022, 21: 365-377.
(10)Li, Ji; Qiu, Jiayue;Han, Junwei;Li, Xiangmei; Jiang, Ying;Tumor Microenvironment Characterization in Breast Cancer Identifies Prognostic Pathway Signatures,Genes, 2022, 13(11): 1976.
(11)Li, Ji; Wu, Jiashuo;Han, Junwei;Analysis of Tumor Microenvironment Heterogeneity among Breast Cancer Subtypes to Identify Subtype-Specific Signatures,Genes,2022, 14(1): 44.
(12) Han, Xudong; Kong, Qingfei; Liu, Chonghui; Cheng, Liang;Han, Junwei;SubtypeDrug:asoftware package for prioritization of candidate cancer subtype-specific drugs.,Bioinformatics, 2021, 37(16): 2491-2493
(13) Sheng, Yuqi; Jiang, Ying; Yang, Yang; Li, Xiangmei; Qiu, Jiayue; Wu, Jiashuo; Cheng, Liang;Han, Junwei;CNA2Subpathway: identification of dysregulated subpathway driven by copy numberalterations in cancer.,Briefings in Bioinformatics,2021, 22(5): bbaa413
(14)Han,Junwei;Han, Xudong; Kong, Qingfei; Cheng, Liang;psSubpathway:asoftware packagefor flexible identification of phenotype-specific subpathways in cancer progression.,Bioinformatics,2020, 36(7): 2303-2305
(15) Di, Jieyi; Zheng, Baotong; Kong, Qingfei; Jiang, Ying; Liu, Siyao; Yang, Yang; Han, Xudong; Sheng, Yuqi; Zhang, Yunpeng; Cheng, Liang;Han, Junwei;Prioritization of candidate cancer drugs based onadrug functional similarity network constructed by integrating pathway activitiesand drug activities.,Molecular Oncology, 2019, 13(10): 2259-2277
(16) Han, Xudong; Wang, Donghua; Zhao, Ping; Liu, Chonghui; Hao, Yue; Chang, Lulu; Zhao, Jiarui; Zhao, Wei; Mu, Lili; Wang, Jinghua; Li, Hulun; Kong, Qingfei;Han, Junwei;Inference of Subpathway Activity Profiles Reveals Metabolism Abnormal Subpathway Regions in Glioblastoma Multiforme,Frontiers in Oncology, 2020, 10: 1549
(17)Wang,Qian;Li,Xiangmei;Wang,Yahui;Qiu Jiayue;Wu,Jiashuo;He,Yalan Li,Ji;Kong,Qingfei;Han,Junwei;Jiang,Ying;Development and Validation of a Three-Gene Prognostic Signature Based on Tumor Microenvironment for Gastric Cancer,Front. Genet., 2022 Feb 1;12:801240.
(18)Han,Junwei;Liu, Siyao; Jiang, Ying; Xu, Chaohan; Zheng, Baotong; Jiang, Minghao; Yang,Haixiu; Su, Fei; Li, Chunquan; Zhang, Yunpeng;Inference of patient-specific subpathway activities revealsafunctional signature associated with the prognosis of patients with breast cancer,Journal of Cellular and Molecular Medicine,2018, 22(9): 4304-4316
(19) Li, Chunquan; Wang, Qiuyu; Ma, Jiquan; Shi, Shengshu; Chen, Xin; Yang, Haixiu;Han, Junwei;Integrative Pathway Analysis of Genes and Metabolites Reveals Metabolism Abnormal SubpathwayRegions and Modules in Esophageal Squamous Cell Carcinoma.,Molecules,2017, 22(10): pii: E1599
(20) Liu Siyao; Zheng Baotong; Sheng Yuqi; Kong Qingfei; Jiang Ying; Yang Yang; Han Xudong; Cheng Liang; Zhang Yunpeng;Han Junwei;Identification of Cancer Dysfunctional Subpathways by Integrating DNA Methylation, Copy Number Variation, and Gene-Expression Data,Frontiers in Genetics,2019, 10: 0-441
(21) Jiang, Ying; Zheng, Baotong; Yang, Yang; Li, Xiangmei;Han, Junwei;Identification of Somatic Mutation-Driven Immune Cells by Integrating Genomic and Transcriptome Data.,Front Cell DevBiol,2021, 2021(9): 715275
(22) Li, Chunquan;Han,Junwei;Shang, Desi; Li, Jing; Wang, Yan; Wang, YingYing; Zhang, Yunpeng; Yao, Qianlan; Zhang, Chunlong; Li, Kongning; Li, Xia;Identifying disease related sub-pathways for analysis of genome-wide association studies,Gene,2012, 503(1): 101-109
(23) Li, Chunquan;Han,Junwei;Yao, Qianlan; Zou, Chendan; Xu, Yanjun; Zhang, Chunlong; Shang,Desi; Zhou, Lingyun; Zou, Chaoxia; Sun, Zeguo; Li, Jing; Zhang, Yunpeng; Yang, Haixiu; Gao, Xu;Li, Xia;Subpathway-GM: identification of metabolic subpathways via joint power of interestinggenes and metabolites and their topologies within pathways,NUCLEIC ACIDS RESEARCH, 2013, 41(9)
(24) Cheng, Liang; Zhao, Hengqiang; Wang, Pingping; Zhou, Wenyang; Luo, Meng; Li, Tianxin;Han,Junwei;Liu, Shulin; Jiang, Qinghua;Computational Methods for Identifying Similar Diseases.,Molecular Therapy-Nucleic Acids, 2019, 18: 590-604
(25)Han,Junwei;Liu, Siyao; Sun, Zeguo; Zhang, Yunpeng; Zhang, Fan; Zhang, Chunlong; Shang,Desi; Yang, Haixiu; Su, Fei; Xu, Yanjun; Li, Chunquan; Ren, Huan; Li, Xia;LncRNAs2Pathways: Identifying the pathways influenced byaset of lncRNAs of interest based onaglobal network propagation method,SCIENTIFIC REPORTS,2017,7
(26)Han,Junwei;Li, Chunquan; Yang, Haixiu; Xu, Yanjun; Zhang, Chunlong; Ma, Jiquan; Shi, Xinrui; Liu, Wei; Shang, Desi; Yao, Qianlan; Zhang, Yunpeng; Su, Fei; Feng, Li; Li, Xia;Anoveldysregulated pathway-identification analysis based on global influence of within-pathway effectsand crosstalk between pathways,JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2015, 102(12): 20140937
(27)Han,Junwei;Shi, Xinrui;Zhang,Yunpeng;Xu,Yanjun;Jiang,Ying;Zhang, Chunlong;Feng,Li;Yang,Haixiu;Shang, Desi;Sun, Zeguo;Su,Fei;Li,Chunquan;Li,Xia；ESEA: Discovering theDysregulatedPathways based onEdge Set Enrichment Analysis,SCIENTIFIC REPORTS,2015,7
